Thrombophilia is a condition in which the blood has an increased tendency to clot. Normally, blood clots form to stop bleeding after an injury and dissolve once healing begins. In thrombophilia, this balance is disturbed, causing clots to form too easily or remain longer than necessary.
Because blood vessels deliver oxygen to vital organs, abnormal clots can block circulation and lead to serious complications such as deep vein thrombosis, pulmonary embolism, stroke, heart attack, or pregnancy loss.
Types of Thrombophilia
There are two main types of thrombophilia.
I
nherited (genetic) thrombophilia
is passed down from one or both parents. It occurs when clot-controlling proteins are missing or not working properly. Common inherited forms include Factor V Leiden, prothrombin gene mutation, and deficiencies of protein C, protein S, or antithrombin.
Acquired thrombophilia
develops later in life due to medical conditions, medications, or lifestyle factors. The most common and severe acquired form is antiphospholipid syndrome, which greatly increases clotting risk.
Symptoms
Many people with thrombophilia have no symptoms until a blood clot forms. Symptoms depend on the clot’s location and may include:
• Swelling, pain, or warmth in an arm or leg
• Sudden chest pain or shortness of breath
• Severe headache, speech or vision problems
• Recurrent miscarriages
Any suspected clot requires immediate medical attention.
Risk Factors
Certain factors increase the likelihood of clot formation, especially in people with thrombophilia:
• Prolonged immobility, surgery, or hospitalization
• Pregnancy, smoking, or obesity
• Cancer, chronic illness, or estrogen-containing hormones
• Family history of blood clots
Diagnosis and Treatment
Diagnosis is based on medical history, blood tests, and imaging studies such as ultrasound or CT scans. Testing is often recommended for people with unexplained or early-onset clots or repeated pregnancy loss.
There is no cure for inherited thrombophilia, but it can be managed. Treatment usually includes blood-thinning medications and, in some cases, compression stockings or emergency clot-dissolving therapy.
Conclusion
Thrombophilia affects how the body controls blood clotting, but most people with the condition never develop a clot. With proper awareness, preventive measures, and medical care, thrombophilia can be safely managed, allowing individuals to live healthy and active lives.