Angioedema (Quincke's edema) is a condition that causes sudden swelling in the deeper layers of the skin and soft tissues. Unlike hives, which appear on the surface of the skin, angioedema develops underneath it, often affecting the lips, eyelids, face, tongue, hands, feet, or other parts of the body.
Although many cases are mild and resolve within a few hours or days, angioedema should never be underestimated. When swelling affects the tongue, throat, or airways, it can rapidly interfere with breathing and become life-threatening. Recognizing the warning signs and seeking prompt medical care can be crucial.
What causes angioedema?
Angioedema occurs when fluid leaks from small blood vessels into nearby tissues, leading to swelling. It can be triggered by allergies, medications, infections, or certain underlying health conditions.
Common causes include:
• Food allergies, insect stings, latex allergy and contact with animals that trigger allergic reactions
• Medications, especially some blood pressure drugs known as ACE inhibitors
• Hereditary angioedema, a rare genetic condition that causes recurrent swelling episodes
In some people, no specific cause can be identified.
What are the symptoms?
The most noticeable symptom is sudden swelling beneath the skin. The lips, eyelids, face, tongue, and throat are among the areas most often affected.
Some people may also experience abdominal pain, nausea, vomiting, diarrhea, dizziness, or fainting. Hives can occur at the same time, although angioedema may develop without any rash.
When is it an emergency?
Angioedema requires immediate medical attention if swelling involves the tongue, throat, or airways. In severe cases, the swelling can progress quickly and partially or completely block airflow to the lungs.
Seek emergency help if you experience:
• Difficulty breathing or wheezing
• Trouble swallowing or a feeling of throat tightness
• Severe dizziness, weakness, or fainting
Delaying treatment can have serious consequences. As swelling increases, breathing may become increasingly difficult, oxygen levels can fall, and the condition may become life-threatening. For this reason, any sudden swelling of the tongue, throat, or lips should be treated as a medical emergency until evaluated by a healthcare professional.
How is angioedema diagnosed and treated?
Doctors usually diagnose angioedema based on symptoms, medical history, and possible triggers. Allergy tests, blood tests, or genetic testing may be recommended in some cases.
Treatment depends on the underlying cause. Antihistamines, corticosteroids, and epinephrine may be used for allergic reactions, while people with hereditary angioedema may require specialized medications. Avoiding known triggers is an important part of preventing future episodes.